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To the Editor:—
As an investigator concerned for many years with the clinical evaluation of steroid agents, I should like to enter a vigorous protest against a policy and reviewership which permits publication of the article by Whitelaw et al.The author states that he is reporting 24 patients "with normal menstrual cycles." In fact, the reasons given in the Table for treatment of cases 4 and 6 are "regulate cycles" and in case 20, "irregular cycles." Steroid treatment is blamed for infertility in case 8, which is in fact a nulligravida. The authors consider amenorrhea following the injection of medroxyprogesterone acetate as a side-effect, when in fact this very property is wellknown and is being applied for contraceptive purposes. The use of an agent in a condition such as threatened abortion is endocrinologically ill-advised....As might be expected, this report has already captured the eye of the lay press
Goldzieher JW. The Pill. JAMA. 1966;196(3):300. doi:10.1001/jama.1966.03100160150055