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May 16, 1966

Hydrogen Infusion: Heart Output Guide

JAMA. 1966;196(7):42. doi:10.1001/jama.1966.03100200024011

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Dissolvedppears to be a useful indicator for rapidly repeated determinations of cardiac output, two western New York investigators report.

The technique, studied initially with dogs, now is being applied as part of presurgical cardiac evaluation of some human patients, Francis J. Klocke, MD, told JAMAMedical News.

This application to humans is promising, he said, but at least six months more work is needed before results can be reported in any detail.

The other member of the research team is David G. Greene, MD. Both investigators are in the Department of Medicine, State University of New York, Buffalo School of Medicine: Dr. Greene as professor of clinical research in cardiovascular disease and Dr. Klocke as assistant professor of medicine.

Indicator Dilution Work  Working primarily with closed-chest spontaneously ventilating dogs, Dr. Klocke told the Federation of American Societies for Experimental Biology, they used the constant rate injection technique described by physiologist

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