May 16, 1966

Gastric Analysis

Author Affiliations

From the departments of medicine, the Genesee and Strong Memorial hospitals, the University of Rochester (NY) School of Medicine and Dentistry.

JAMA. 1966;196(7):655. doi:10.1001/jama.1966.03100200095029

The renaissance of interest in the gastric mucosa has produced both a more exact knowledge of the physiology of gastric secretion and new tools for clinical application.

Recent investigations have resulted in the demonstration of four distinct human pepsinogens and pepsins1 and the isolation of two pure gastrins.2 Tubeless tools are available to determine the capability of gastric mucosa to secrete acid, pepsinogens, and intrinsic tumor. Intubation techniques allow estimation of parietal cell population (maximum acid output)3 and determination of the percentage of the parietal cells secreting under basal conditions and after vagotomy. Assay methods4,5 have been developed to measure intrinsic factor in gastric juice aspirate.

All this signifies that gastric analysis is not only a test to determine the acidity of aspirated gastric juice, but also a means to measure the basal and maximum acid outputs and the capability of the gastric mucosa to secrete

First Page Preview View Large
First page PDF preview
First page PDF preview