June 6, 1966


JAMA. 1966;196(10):908-909. doi:10.1001/jama.1966.03100230152039

More than three fourths of the patients who are born with situs inversus also have other major congenital malformations. It is therefore important to recognize before operating that this condition exists. Although several of the anomalies may be corrected surgically, a few, such as those associated with splenic agenesis and included in Ivemark's syndrome, are so severe that they rarely benefit by attempts at curative or even palliative surgical procedures. Visceral reversal may be total or partial and may affect various organ systems. Dextrocardia may occur with or without situs inversus and, when present, usually indicates that other serious malformations are also present. Complete visceral transposition is believed to be inherited as a recessive characteristic which is determined by a single autosomal gene.1

A communication in a recent issue of the Archives of Surgery directs attention to the intraabdominal malformations that accompany situs inversus in almost half of the

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