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To the Editor:—
The authors state that "most of the patients" had unexplained nasal symptoms before ragweed pollen appeared in the air. Were not these symptoms due to unidentified allergens, which predisposed to a continuation of symptoms? Additionally, a diseased nasal mucosa might remain, still sensitive to almost any stimulus for weeks.Their study involved the less frequently used preseasonal injection method, with the maximum tolerated doses given at weekly intervals during the height of the ragweed pollen season. The great American philosophy that, if a little is good, more is better, should not apply here. Most patients suffer aggravated symptoms, even without systemic reactions, if a maximum dose of allergen is injected during the pollen season. Therefore, overdosage could account for the failure of these authors to demonstrate effectiveness.
Mansmann HS. Hyposensitization Therapy In Ragweed Hay Fever. JAMA. 1966;196(11):1025. doi:10.1001/jama.1966.03100240159048