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To the Editor:—
Dr. Fontana states that no children were included in the study who were sensitive to inhalants other than ragweed. He further adds that most of his patients were not entirely void of symptoms preceding the ragweed season. It is very rare to find a patient with symptoms during the fall hay-fever season who is not reactive to dust, epidermoids, and other minor weeds. In over 500 patients in my private practice and clinic experience, I have yet to find one in whom ragweed is the only reactant. Dr. Fontana has apparently found 70. If one is interested in a double-blind evaluation of hyposensitization therapy with ragweed alone, the treatment mixture should contain all pertinent weeds, dust, molds, and epidermoids, and the placebo mixture should contain these ingredients, omitting the ragweed.
Josephson BM. Hyposensitization Therapy In Ragweed Hay Fever. JAMA. 1966;196(11):1025. doi:10.1001/jama.1966.03100240159049