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To the Editor:—
In assessing the controversy between Drs. Fontana and Lowell, the principal point of agreement seems to be that of the difficulty of measuring symptoms and therapeutic results, both by patient and by physician observer. No amount of objectivity by the most unbiased of observers has been able to circumvent the inherent differences between patients, or between symptoms, in this variable disease.When observations are inconsistent, are not of high degree of accuracy, or vary with different observers, the scientific method demands that other means of ascertaining the truth be employed.The first of these available to the investigator is that of reason. Do these observations make sense, and can some rational explanation be made?When hyposensitization is examined in this light, it is found that the originators of this form of therapy, Noon and Freeman, believed that allergens were synonymous with toxins and that they were immunizing
Robbins JJ. A Comedy of Errors. JAMA. 1966;196(11):1026. doi:10.1001/jama.1966.03100240159051