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July 11, 1966

Correlation of Myocardial and Renal Necrosis With Tissue Electrolyte Changes

Author Affiliations

From the Department of Pharmacology, New York Medical College, Flower and Fifth Avenue Hospitals, New York.

JAMA. 1966;197(2):105-112. doi:10.1001/jama.1966.03110020093031

It is known that degeneration and necrosis of tissue is associated with substantial changes in the electrolyte content of affected areas. It is not certain, however, whether such alterations are solely one of the consequences of tissue injury, or whether certain electrolyte shifts contribute to the elicitation of organic damage. In favor of a causative influence of electrolyte shifts, one may cite the fact that severe myocardial injury can be produced by dietary deficiency of potassium or magnesium, the two most important intracellular cations, and that the severity of cardiac lesions induced by dietary and other means can be enhanced by sodium-loading or by mineralocorticoids, and inhibited by the administration of potassium and magnesium salts.

Primary Goals  The primary goals of the present investigation were the following: (1) to search for possible similarities in the derangement of the electrolyte pattern occurring in myocardial necrosis produced by different means, (2) to

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