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July 11, 1966

Protective Effect of Influenza Immunization

Author Affiliations

Los Angeles

JAMA. 1966;197(2):153. doi:10.1001/jama.1966.03110020141056

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To the Editor:—  For several years a voluntary annual program of influenza immunization has been offered to employees by the Health Service of Occidental Life Insurance Company of California. In September and October 1965 the usual program was carried out, a single subcutaneous injection of 1 ml of polyvalent influenza vaccine being given to persons who had been immunized the previous year and two subcutaneous injections of 1 ml each at a four-week interval to those who had not received the vaccine for over one year. The vaccine used contained five virus strains in the A2, A, A1 and B groups.There was an outbreak of influenza in the Los Angeles area in February 1966 which was associated with an increase in illness absenteeism among our employees. The Los Angeles County Health Department identified an A2 ( Asian) influenza virus as the causative agent. From Feb 14 through

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