Thirty-two patients with far advanced neoplastic diseases were treated with floxuridine therapy by continuous infusion. Three of 19 patients with gastrointestinal neoplasms obtained a response to treatment and four additional patients had a beneficial effect from therapy. Four of five patients with carcinoma of the breast had a response to the drug and in two of these, the duration of the response exceeded a year. These results were achieved with minimal associated side effects.
Papac RJ, Calabresi P. Infusion of Floxuridine in the Treatment of Solid Tumors. JAMA. 1966;197(4):237-241. doi:10.1001/jama.1966.03110040047012