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July 25, 1966

Infusion of Floxuridine in the Treatment of Solid Tumors

Author Affiliations

From the departments of medicine and pharmacology, Yale University School of Medicine. New Haven, Conn. Dr. Calabresi is a Burroughs-Wellcome Scholar in Clinical Pharmacology.

JAMA. 1966;197(4):237-241. doi:10.1001/jama.1966.03110040047012

Thirty-two patients with far advanced neoplastic diseases were treated with floxuridine therapy by continuous infusion. Three of 19 patients with gastrointestinal neoplasms obtained a response to treatment and four additional patients had a beneficial effect from therapy. Four of five patients with carcinoma of the breast had a response to the drug and in two of these, the duration of the response exceeded a year. These results were achieved with minimal associated side effects.