August 1, 1966

Rare Diagnosis: Sarcoid Arthritis In Four Children

JAMA. 1966;197(5):31. doi:10.1001/jama.1966.03110050017005

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What appears to be a clinical syndrome of sarcoid arthritis in children was described at the annual meeting in Denver of the American Rheumatism Association.

Sarcoidosis is rare in children, and it is not possible to differentiate it unequivocally from juvenile rheumatoid arthritis. Nevertheless, the clinical and pathological findings in four children were sufficiently distinct to prompt a group of investigators to make a diagnosis of sarcoid arthritis.

These children had large, boggy —but painless—synovial and tendon sheath thickening and effusions. There was little limitation of motion, and constitutional symptoms were minimal or absent.

The disease followed an indolent clinical course. All had the onset of symptoms before age 4. As they grew older, joint and tendon sheath manifestations became less distinctive and more like those of rheumatoid disease; there was morning stiffness, limitation of motion, neck involvement and fusiform swelling of the fingers.

All four children had uveitis with