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To the Editor:—
I cannot agree with Dr. Ruben that the statement which I made concerning the intravenous use of local anesthetics is incorrect. While it is true that they are used by certain clinicians for a variety of purposes, these drugs have little to offer therapeutically by the intravenous route when one considers their lethal potential. The same thing may be accomplished by using other drugs which are safer. Their clinical usefulness, systemically, is limited and once again I say, there is little or no justification for using them for their systemic effects.
Adriani J. Systemic Use of Local Anesthetics. JAMA. 1966;197(8):666. doi:10.1001/jama.1966.03110080105043