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September 26, 1966

Dimethyl Sulfoxide A Correction

Author Affiliations


JAMA. 1966;197(13):1109. doi:10.1001/jama.1966.03110130109043

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To the Editor:—  I wish to inform you of a regrettable inaccuracy in Part 2 of my paper entitled, "Topical Pharmacology and Toxicology of Dimethyl Sulfoxide" (193:923 1965). Owing to inadequate supervision on my part the statements under the section labeled "Chronic Exposure" (p 925) are not fully supported by the experimental procedures.Twenty men were to have received 9 ml of 90% dimethyl sulfoxide to the trunk once daily for 24 weeks. Actually the study was stopped at 16 weeks. Moreover, some subjects dropped out before this time for unrelated reasons. One, however, experienced giant hives on the trunk at night, a few days after starting. He was not continued. In reviewing the summation of the toxicologic data I failed to note this happening, although it was duly noted on the chart. I did however call attention to the possibility of histamine mediated shocklike syndromes. Since 20 subjects