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October 10, 1966

Excess FSH May Cause Luteoma

JAMA. 1966;198(2):40. doi:10.1001/jama.1966.03110150020007

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Luteoma of pregnancy, a tumor of J the ovaries, may be due to an excessive pituitary secretion of follicle stimulating hormone (FSH).

This suggestion was made by a group of investigators at Sinai Hospital, Detroit, and the Wayne State University College of Medicine in a report to the annual meeting of the American Society of Clinical Pathologists.

Reactive Hyperplasia  "We believe the luteoma of pregnancy is a reactive hyperplasia and is peculiar to the third trimester of pregnancy," said Gerald Mandell, MD. "It is hormonally functional and is probably dependent upon the pituitary for its development."It has been shown by other investigators that follicle formation and ovulation may occur within several days after delivery.Dr. Mandell and his co-workers, William S. Floyd, MD; S. Leonard Cohn, MD; and Paul A. Goodman, MD, suggest that through an error in secretion of the gonadotrophins at term, follicles might occur prematurely. Such