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October 10, 1966

Malignant Transformation by Viruses

JAMA. 1966;198(2):212. doi:10.1001/jama.1966.03110150160058

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This presentation of the various aspects of the malignant transformation by viruses has three major subdivisions: characteristics, genetics and immunology, and significance. The subjects covered include the following: transformation of hamster fibroblasts by polyoma virus, effects of Rous sarcoma virus on cultured chicken and duck cells, tumor development with polyoma virus in submandibular glands of newborn mice as influenced by symbiosis of epithelial and mesenchymal elements, tumor development with polyoma virus in metanephric tissue of rat embryo, effect of mammary tumor virus on epithelial cells of mouse breast in vitro, specific antigens produced by several oncogenic viruses, influence of infective symbiosis of defective oncogenic viruses, effects of adenovirussimian virus 40 hybrid on weanling hamster kidney cultures, effects of simian virus 40 on human diploid fibroblast-like cells, growth rate and tumor-forming potential of normal, malignant, and simiam virus 40 transformed euploid cells of Chinese and Armenian hamsters, immunization against viruses as