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October 17, 1966

Nephrotic Syndrome Associated With Congenital Syphilis

Author Affiliations

From the Kings County Medical Center, Brooklyn, NY. Dr. Pollner is now assigned to the Food and Drug Administration, US Public Health Service, Arlington, Va.

JAMA. 1966;198(3):263-266. doi:10.1001/jama.1966.03110160091028

Congenital syphilis is a rare but definite cause of the nephrotic syndrome. The lesion has not been previously reported in patients with the acute form of the disease and only recently has been demonstrated in patients with acquired syphilis. Renal alterations demonstrated by open kidney biopsy in a patient with congenital syphilis and the nephrotic syndrome were compatible with those seen in patients with membranous glomerulonephritis and in patients with the acquired form of the disease.