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October 24, 1966

Detection of Narcotic Drugs, Tranquilizers, Amphetamines, and Barbiturates in Urine

Author Affiliations

From the Rockefeller University, New York.

JAMA. 1966;198(4):349-352. doi:10.1001/jama.1966.03110170061017

A method for detection in urine of narcotic drugs, quinine, barbiturates, amphetamines, and some tranquilizers appears to be applicable to a wide range of diagnostic problems and epidemiological studies. The drugs are first absorbed on ion-exchange paper and then eluted with a series of buffer-solvent systems. An aliquot of the solvent phase is concentrated and chromatographed. A series of detection sprays have been developed to provide both sensitive detection and confirmation of positive results.