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October 31, 1966

ALS Trials Prove Encouraging

JAMA. 1966;198(5):35-36. doi:10.1001/jama.1966.03110180015004

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Clinical trial of anti-lymphocyte serum (ALS) as an immunosuppressive agent in patients with renal homografts has been reported by investigators at the University of Colorado Medical School.

Thomas E. Starzl, MD, and Thomas L. Marchioro, MD, told the annual Clinical Congress of the American College of Surgeons that serum derived from horses immunized against human lymphocytes has been used in 13 patients.

Preliminary Results  Preliminary results indicate that patients given ALS can be maintained on markedly reduced levels of steroids."The true effectiveness of antilymphocyte serum as an immunosuppressive agent in humans will not be known, however, until we can perform biopsies on patients receiving ALS," Dr. Starzl recently told JAMA Medical News.The report by the Denver group was one of several describing clinical experience with new immunosuppressive techniques.Others included a report by Nicholas L. Tilney, MD, and Joseph E. Murray, MD, on the use of thoracic duct