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A dministration of a balanced salt solution throughout the operative period during major abdominal surgery replaces extracellular fluid volume lost as a result of operative trauma.
Moreover, correction of this volume deficit during surgery avoids postoperative salt intolerance, stated Charles J. Carrico, MD.In a clinical study by G. Tom Shires, MD, and his co-workers at University of Texas Southwestern Medical School, Dallas, C. Dale Coln, MD, and Dr. Carrico, plasma volume, erythrocyte mass, and extracellular fluid volume were followed in patients undergoing abdominal surgery uncomplicated by hypotension.Postoperative changes in extracellular fluid volume, other than that incurred as operative blood loss, could not be demonstrated in patients undergoing minor procedures.In patients undergoing major abdominal surgery, however, there was a decrease in extracellular fluid volume of up to 28% (3,721 cc) in those receiving only small intravenous amounts of 5% dextrose in water; this loss correlated only
Salt Solution During Surgery. JAMA. 1966;198(5):38. doi:10.1001/jama.1966.03110180018007