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October 31, 1966

Treatment of Haemophilia and Other Coagulation Disorders

JAMA. 1966;198(5):565-566. doi:10.1001/jama.1966.03110180109044

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Doctors Biggs and Macfarlane, in this monograph, summarize their experience with the therapy of hemophilia and other coagulation disorders. They and their colleagues are well qualified to speak on this subject and this book reflects their competence in this area.

The first chapter deals with the normal hemostatic mechanism as visualized by Professor Macfarlane. It is imaginatively written and should certainly stimulate interest, if not controversy, among its readers. His "cascade" theory of blood coagulation, while not proven, has gained wide acceptance in this country as well as others. Following this section is a chapter on the diagnosis of hemorrhagic diseases which is somewhat limited in scope and is more adequately covered in other monographs.

After the introductory chapters, a large segment deals with the preparation of the therapeutic materials useful in hemophilia and Christmas disease. A great deal of stress is put upon the use of Factor VIII (antihemophilic