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December 5, 1966


JAMA. 1966;198(10):1117. doi:10.1001/jama.1966.03110230133034

The last half-century has witnessed numerous biochemical investigations of the body fluids and tissues of psychiatrically ill patients, and a variety of biological abnormalities in schizophrenic and manic-depressive illnesses have been claimed by competent investigators, only later to be disclaimed or to be found lacking in confirmation from other laboratories.

Kallman, Slater, and others have collected a large amount of statistical data which indicate that a genetic factor is operative in schizophrenia, and this has served as the main impetus for investigators attempting to detect differences between schizophrenics and normal subjects in their body tissues, urine, and peripheral blood.

Among the last-mentioned claims is that of Kamp1 who, in 1962, stated that he found an abnormality in the nuclear morphology of the lymphocytes of schizophrenics by use of Masson's trichrome stain; but this was not supported by the findings of other investigators. Fessel and Harata-Hibi in 1963 went on