December 12, 1966

Vaccine-Acquired Poliomyelitis in An Unvaccinated Mother

Author Affiliations

San Francisco

JAMA. 1966;198(11):1224. doi:10.1001/jama.1966.03110240132055

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To the Editor:—  The paper, "Vaccine-Acquired Paralytic Poliomyelitis in an Unvaccinated Mother" (197:1034, 1966), has some disturbing implications, medicolegal applications which may be unfortunate, and certain defects of factual information on which conclusions are based.This report of a single case describes a paralytic illness involving, to a variable extent, all four extremities of a 43-year-old mother whose infant had been given trivalent, live oral poliovirus vaccine 22 days before the onset of her symptoms. The course of disease was compatible with the diagnosis of poliomyelitis, type II virus was isolated from the patient's stool specimens, and her antibodies against type II virus rose from 1:20 on the ninth day of disease to 1:80 on the 32nd day. The clinical picture is similar to poliomyelitis in many respects and naturally caused suspicion that exposure to the vaccinated child might have been the source of infection. Identification of the virus