December 12, 1966

Hormones and Hypertension

Author Affiliations



compiled and edited by William M. Manger, 265 pp, with illus, Springfield, Ill: Charles C Thomas, Publisher, 1966.

JAMA. 1966;198(11):1226. doi:10.1001/jama.1966.03110240134060

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This slim volume views through the eyes of experts some current theories of hypertension. The editor gathered 13 other top investigators, gave them nine chapters to write, and weeded out the chaff.

This bookmaking formula yields a richly-documented, virtually error-free work. The dustjacket calls it a "superb synthesis" of hypertension and endocrine disturbances; I would classify it a series of review articles covering the last 30 years of hypertension. Some chapters are excellent. Jerome Conn makes a good case for aldosteronism as a leading cause of essential hypertension; James McCubbin and Irving Page wrap the various theories of renal hypertension into a "unifying" package; Louis Tobian probes the mysteries of the juxtaglomerular apparatus; and others tread through the metabolic mazes of epinephrine, norepinephrine, rennin, angiotensin, and the steroids. Two of the chapters—those linking elevated blood pressure with pregnancy and hyperthyroidism—are difficult to follow. Pregnancy and thyroid disease are backward handmaidens