Corticotropin or prednisolone was used to treat 66 students who had severe but uncomplicated mononucleosis, after it was clinically apparent that the illness was worsening under conservative management. Treated patients included those with anginose, typhoidal, and hepatic syndromes. Duration of fever after starting treatment was used to assess the drug effect. Each treated patient was matched with an untreated patient which resulted in 66 pairs of patients having minimal biologic variations as well as very similar clinical syndromes and fever ranges. A comparison of the febrile periods in the matched pairs showed an average period of 5.6 days for the untreated group and 1.4 days for the treated group. The difference, 4.2 days, was highly significant.
Bender CE. The Value of Corticosteroids in the Treatment of Infectious Mononucleosis. JAMA. 1967;199(8):529–531. doi:10.1001/jama.1967.03120080063009