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March 20, 1967


JAMA. 1967;199(12):928. doi:10.1001/jama.1967.03120120116023

The occurrence of retinopathy in infants and children whose mothers had rubella in the first trimester of pregnancy was originally documented by Gregg in 1942.1 The disease consists of a pigment disturbance most often involving the posterior pole of the eye and most marked in the macula region. It may occur in one or both eyes and has been described as small black irregular masses varying in size and often accompanied by a waxy disk.2 The great majority of the infants and children had, in addition, one or more stigmata of congenital rubella, deafness, cataracts, cardiac lesions, and mental retardation.

In a recent communication in the American Journal of Diseases of Children,3 the authors reported eight cases of rubella retinitis, five in infants with congenital rubella syndrome following the 1964-1965 epidemic, two in 6-year-old children with congenital rubella who were born during the 1958-1959 outbreak, and one