A mumps epidemic occurred on St. George Island, Alaska, among a population which had not been exposed to mumps since 1907. During a 15-week period clinical mumps were observed in 119 of 212 native residents, while an additional 37 residents had serologic evidence of subclinical infections. Prophylactic mumps hyperimmune γ-globulin given to 56 persons who were clinically and serologically susceptible did not appear to reduce the attack rates or to prevent clinical complications.
Reed D, Brown G, Merrick R, Sever J, Feltz E. A Mumps Epidemic on St. George Island, Alaska. JAMA. 1967;199(13):967-971. doi:10.1001/jama.1967.03120130053007