Lactic Acidosis in Diabetes Mellitus
An ACCUMULATION OF LACTIC ACID in the L blood, sufficient to decrease the serum bicarbonate and the pH, has been observed in both diabetic and nondiabetic patients. The significance of this was discussed on Nov 17, 1962, during a conference in New York on nonketotic metabolic acidosis in diabetes mellitus. The conclusions reached are herein summarized.Lactic acidosis is a group of syndromes for which Huckabee's classification (Amer J Med30:833, 840, 1961) provides a useful frame of reference.
—Lactic acid (L) is slightly increased above the basal value of approximately 1 mM/liter in venous blood and there is a proportionate percentage increase in pyruvic acid (P) with maintenance of the usual 10:1 L/P ratio. This has been observed in patients who are hospitalized because of miscellaneous diseases and can be produced in patients or healthy subjects by muscular tension, exercise, hyperventilation,
Special Communication. JAMA. 1963;184(1):47. doi:10.1001/jama.1963.03700140103015