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April 13, 1963

Appraisal of Methysergide in Treatment of Vascular Headaches of Migraine Type

Author Affiliations

New York City

From the Headache Unit, Division of Neurology and the Medical Division, Montefiore Hospital; College of Physicians and Surgeons, Columbia University.

JAMA. 1963;184(2):125-128. doi:10.1001/jama.1963.03700150079013

The authors administered methysergide maleate to 421 patients who previously had been treated, without success, for recurrent headaches over periods as long as 55 yr. The drug was given in amounts ranging from 6 to 16 mg per day in divided doses. The treatment, essentially prophylactic, was continued for periods up to 29 mo. Side effects were frequent and adjustment of dosage was necessary. The data led to the conclusion that methysergide maleate has no value in treating the acute attack, but is effective in the prophylactic treatment of all forms of migraine headache.