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April 13, 1963

Ultraviolet Hemolysis in Hematologic Disorders

Author Affiliations

Los Angeles; San Francisco

From the Cancer Research Institute of the University of California School of Medicine, San Francisco.; Dr. Marshall's present address is Wadsworth General Hospital, Veterans Administration Center, Los Angeles 25. A medical student research fellow from 1959, he received his MD degree in June, 1961.; Miss Tsang, a medical student research fellow, will receive her MD degree in June, 1963.

JAMA. 1963;184(2):139-141. doi:10.1001/jama.1963.73700150011017

PRIOR STUDIES by Sonne1 and by Blum and Cook2-5 have been concerned with the mechanism and kinetics of hemolysis induced by ultraviolet energy. No clinical studies of ultraviolet hemolysis (UVH) have been found. Our preliminary abstract6 reported the finding of marked resistance in vitro to UVH in certain diseases. Subsequently we have found that plasma factors, not erythrocyte abnormalities, are largely if not entirely responsible for the increased resistance. In the present report, the disease states associated with resistance to UVH are listed, and the clinical significance and mechanism of the phenomenon are discussed.

Materials and Methods  UVH was studied in 221 subjects. A survey to determine whether abnormal UVH is associated with any particular disease states included 28 healthy persons and 168 patients at the University of California Medical Center and the San Francisco General Hospital. Studies to elucidate the mechanism were made in an

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