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April 13, 1963


JAMA. 1963;184(2):159. doi:10.1001/jama.1963.03700150113024

Cushing's Disease.  —H. P. Klotz and co-workers (Sem Hop Paris38:3189 [Oct 14] 1962) discussed two cases of dramatic recovery from Cushing's disease. The authors reminded the reader that the customary treatment by total bilateral adrenalectomy gives relatively good results, but the diencephalic hypophyseal hypertonia, which is at the root of the syndrome, remains unchanged and may even worsen through surgical intervention. A cutaneous pigmentation may occur after operation and even a macroscopic adenoma of the pituitary body may be found.The authors treated two patients with intrahypophyseal implantations of radioactive products. The first patient was a 17-yr-old Algerian woman who had a clear case of Cushing's syndrome. This patient was administered 25 mc of radioactive gold intrahypophyseally. This procedure does not totally destroy the hypophysis but causes partial destruction and acts as a brake on the function of the hypophysis and also on that of the diencephalon. Improvement

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