The clinical usefulness of anabolic agents—testosterone and the newer synthetic steroids—has not been clearly defined. After re-examining their position regarding the status of these drugs, the authors conclude that these agents are useful when specific clinical indications exist. Effective use of these compounds depends upon a knowledge of the anabolic effects desired, of the recommended dosage schedule of the drug selected, and of the side effects and contraindications. In the majority of cases, when a clinically effective anabolic agent is needed, the synthetic steroids available at present do not appear to offer any pronounced advantages over the proper use of testosterone.
Fruehan AE, Frawley TF. Current Status of Anabolic Steroids. JAMA. 1963;184(7):527-532. doi:10.1001/jama.1963.03700200049009