May 18, 1963

Incidence of Hypothyroidism

JAMA. 1963;184(7):600. doi:10.1001/jama.1963.03700200122027

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To the Editor:  —The article by Drs. Lowrey and Starr, "Chemical Evidence of Incidence of Hypothyroidism" (JAMA171:2045 [Dec 12] 1959), contains data presented by the authors which do not appear to justify their conclusions.The comprehensive series of protein-bound iodine (PBI) levels reported in the paper provide valuable information, yet the statistical computations are not correct. In order to demonstrate this fact, the data displayed graphically in Fig 3 (serum PBI levels of 735 subjects) were analyzed according to the methods of Snedecor cited by the authors. The appropriate statistics were computed with the use of a digital computer and compared with the values presented in the paper. The comparison is as follows:Certain discrepancies are readily apparent. In particular, the measures of skewness and kurtosis are smaller in magnitude than those cited by the authors and do not indicate marked deviation from a normal distribution.The accuracy

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