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July 27, 1963

Chemical carcinogenesis

JAMA. 1963;185(4):334. doi:10.1001/jama.1963.03060040118050

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The vast body of knowledge on carcinogens that has accumulated during the past 30 years has not only provided significant theoretic insights into causation and pathogenesis of neoplasia, but has also contributed to practical cancer control by pinpointing some occupational and environmental carcinogenic hazards and facilitating their elimination. This book tries to survey the field to acquaint the research chemist with the biochemical and biological aspects of chemical carcinogenesis and to elucidate the chemical phenomena for the physician and biologist. Broadly speaking, these difficult goals have been accomplished with a good measure of success.

Carcinogens identified as causal agents of tumors in specific organs of man are dealt with in the introductory chapter. The subject of testing for carcinogenic activity in animal experimentation, including details of methodology and interpretation, is particularly well presented. The following chapters are devoted to the main categories of carcinogens: inorganic compounds, aromatic hydrocarbons, azo compounds,

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