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August 10, 1963

Factors Involved in Homograft Tolerance

Author Affiliations

Phoenix, Ariz.

JAMA. 1963;185(6):544. doi:10.1001/jama.1963.03060060142029

To the Editor:—  The paper of Aust and Guttmann in the March 9 issue of The Journal (183:857) is the latest in a long line which perpetrates and perpetuates erroneous statements concerning immune "tolerance" induced by pure protein antigens. This error consists in the assertion that persistence of the antigen is responsible for lack of antibody production and that the effect is one of immunological paralysis.Aust and Guttmann cite the work of Smith and Bridges1 as demonstrating "failure to respond to subsequent BSA until the injected reservoir has been metabolized," when in fact Smith and Bridges demonstrated no such thing. Smith and Bridges cited other workers who had given very large doses of antigen and produced temporary paralysis, but in their own work, and in my work which they cited,2 immunological "tolerance" was produced by doses of antigen (as little as 20 mg) which, ordinarily, would result

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