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August 10, 1963

Factors Involved in Homograft Tolerance-Reply

Author Affiliations


JAMA. 1963;185(6):544. doi:10.1001/jama.1963.03060060142030

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The relationship between the duration of the tolerant state and the amount of antigen administered, together with an analysis of the relationship between the amount of antigen administered and the length of the critical period of neonatal life during which such amounts will produce tolerance, have been described in the more definitive publication of Smith and Bridges (J Exp Med108:227, 1958). I believe this data tends to support our concept that the persistence of antigen is associated with lack of antibody production and that the effect is similar to that of immunological paralysis.

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