August 24, 1963

Disseminated Lupus Erythematosus in Identical Twins

Author Affiliations


Resident in Medicine (Dr. Blumenfeld), instructors in medicine (Drs. Kaplan and Mills), and Associate Professor of Medicine and Chief of the Section of Rheumatology (Dr. Clark), University of Tennessee College of Medicine.

JAMA. 1963;185(8):667-669. doi:10.1001/jama.1963.03060080063022

IT HAS BECOME APPARENT in the past few years that lupus erythematosus may be a disease in which hereditary factors are concerned. A review of the literature reveals reports of the occurrence in identical twins of well-documented systemic lupus erythematosus (SLE) by Davis and Gutridge,1 in 1951, and again by Wagenhals and Burgeson,2 in 1958. In addition, discoid lupus erythematosus in identical twins has been reported by Von Gruenhagen3 and again by Steagall and associates.4 The patients in the latter report had some clinical and laboratory features of the disseminated form. There have also been numerous reports of the increased incidence of SLE and the other diffuse connective tissue diseases in the relatives of affected patients.5-7 The association of hypergammaglobulinemia, positive reactions for syphilis, abnormalities in liver function tests, and the presence of antinuclear factors have also been demonstrated in a significant number of asymptomatic

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