August 24, 1963

Atypical Antibodies Present 21 Years After Transfusion

Author Affiliations

New Haven, Conn.

JAMA. 1963;185(8):674. doi:10.1001/jama.1963.03060080070029

To the Editor:—  Recently while crossmatching for a group A, Rh negative, 73-year-old man, we had difficulty finding compatible blood. The patient's serum agglutinated our fresh reference blood in saline solutions and by the indirect antiglobulin method. Using saline solution, albumin, indirect antiglobulin, and papain (Low's method) with an 18-blood panel, we identified three atypical antibodies. The serum contained anti-rh' (C), anti-Rho (D), and anti-Fya. Typing of the patient's cells confirmed the absence of the blood factors rh' (C), Rh0 (D), and Fya. Crossmatches with type A, Rh negative, Fya negative bloods were compatible.Although the finding of three atypical antibodies in one serum is unusual, when it does occur it is most often seen in patients who have received multiple transfusions. Our patient, mildly diabetic, had been in good health most of his life. He had had diverticulitis in 1941, and the only transfusion

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