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August 24, 1963

Connective tissue disorders

JAMA. 1963;185(8):676. doi:10.1001/jama.1963.03060080072035

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Sir John Richardson, physician to St. Thomas' Hospital, London, has prepared a monograph based upon a review of the literature and clinical observations of more than 230 cases distributed among the unusual types of connective tissue disorders. Included in this category are systemic lupus erythematosus, polyarteritis nodosa, scleroderma, and dermatomyositis. The author wisely confesses in the preface that, in his discussion of the pathogenesis of these enigmatic maladies, only the experimental data in molecular biology, immunochemistry, and other complex etiological phenomena, in which he professes competency in understanding, are presented. It is of academic interest that the natural history of each of these afflictions, as observed in England, appears to be quite similar to the counterpart in American experience. Similarly, in treatment, the greatest reliance, according to Richardson, is placed upon minimal doses of the corticosteroids consistent with optimal or suboptimal symptomatic benefit.

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