Minute doses of gamma globulin, eg, 0.1 cc, were given intradermally to a group of allergic children, 4 to 13 years of age, in both an uncontrolled and a controlled series. It was found that this new modality was highly effective in controlling and preventing allergic manifestations resulting from or complicating upper respiratory infections. The gamma globulin used was derived from human placenta rather than from pooled human blood. An attempt was made to develop a working hypothesis for the mode of action of the gamma globulin in these allergic children.
Redner B, Markow H. Effects of Minute Doses of Gamma Globulin in Children with Active Allergic Manifestations. JAMA. 1963;185(9):692-695. doi:10.1001/jama.1963.03060090024009