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Article
Sept 21, 1963

Prediabetes' Research—A Means to Eventual Prevention of Diabetes

JAMA. 1963;185(12):32-33. doi:10.1001/jama.1963.03060120008005

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Abstract

It may be possible someday to prevent diabetes. At least, that is the hope of researchers currently investigating "prediabetes"—that stage so early in the life of a potential diabetic that he is considered normal by conventional standards.

Actually, prediabetes is considered to exist, in a person genetically destined to become diabetic, any time from the beginning of his life until his first abnormal glucose tolerance test.

One of the research groups investigating prediabetes is a team at the Joslin Clinic in Boston. Drs. Searle B. Rees, Rafael A. Camerini-Davalos, James B. Caulfield, Oscar Lozano-Castaneda, Alexander Marble and Santiago Naldjian have developed tests for detecting prediabetes, and are now investigating the deviations from normal that can be detected through these techniques.

Using a study group of non-diabetics, diabetics and prediabetics, matched by sex and age, the researchers made studies of carbohydrate metabolism, renal status, neurological status, vascular conditions, and insulin activity.

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