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Some circulating materials in the plasma may relate to known diabetogenic hormones of the pituitary gland, in the opinion of Dr. Lillian Recant of Washington University School of Medicine in St. Louis.
Accordng to Dr. Recant, most of these materials have specific action on muscle tissue, and inhibit the action of insulin. Since adipose tissue is especially resistant to insulin, the key question of the research is whether or not the circulating materials have any effect in regard to fat tissue.
In all probability, Dr. Recant told the The Journal, there is something in circulation which acts like the diabetogenic substances on fat tissue. Although they do not actually inhibit insulin, they mimic the diabetogenic materials, and so impair the existing condition of the muscle tissue, she reported.
A colleague of Dr. Recant at Washington University, Dr. Haluk Alp, is investigating known inhibitors of muscle tissue and thus far has
Plasma, Insulin and Fat Tissue. JAMA. 1963;185(12):34. doi:10.1001/jama.1963.03060120010008