Moderate to severe systemic intoxication resulting from rapid intravenous injection of 5-fluorouracil in cancer chemotherapy has been reduced from an incidence of 50% to 60% to 6% in a series of 83 patients by use of infusions in 5% glucose over 8 hours. Doses of 10 to 25 gm per patient per course have been tolerated with minimal toxic reactions. There was objective palliation of metastases in 27% from drug therapy alone, and in a further 10% by treatment combined with hormonal or x-ray therapy. Avoidance of intoxication by slow intravenous infusion has broadened the opportunities for use of this drug in ambulatory therapy of colorectal, biliary tract, ovarian, and mammary cancer.
Lemon HM, Modzen PJ, Mirchandani R, Farmer DA, Athans J. Decreased Intoxication by Fluorouracil When Slowly Administered in Glucose. JAMA. 1963;185(13):1012-1016. doi:10.1001/jama.1963.03060130030009