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Article
December 14, 1912

A CLINICOPATHOLOGIC STUDY OF CARBON MONOXID POISONING

Author Affiliations

PHILADELPHIA

From the Department of Neurology and the Laboratory of Neuropathology of the University of Pennsylvania and from the Philadelphia General Hospital.

JAMA. 1912;LIX(24):2122-2126. doi:10.1001/jama.1912.04270120107006
Abstract

REMARKS BY DR. MC CONNELL  Through the courtesy of Dr. Charles K. Mills, I am enabled to make this report of a fatal case of poisoning by carbon monoxid, the patient having died in his service at the Philadelphia General Hospital. As a recital of mere symptoms is almost valueless in these days of search for ultimate conditions, Dr. William G. Spiller kindly undertook the pathologic study and by his unusual findings established a sufficient reason for this presentation. I take this opportunity of expressing my appreciation of Dr. Spiller's kindness in associating his microscopic work with my clinical study.Poisoning by carbon monoxid may be divided into three great classes, the division being determined by the mode of onset of the symptoms: acute poisoning, chronic poisoning and relapsing carbon monoxid poisoning.Under acute poisoning are included those cases in which the manifestations appear very promptly after the exposure of

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