The trend of recent studies in dementia praecox has been toward the physical manifestations of the disease. The earlier writers concerned themselves mostly with the mental sphere and would make their diagnosis chiefly or solely on mental symptoms. But of late, independent of the psycho-analysts and those who urge a more, or less strictly psychogenous origin, investigators of another and more material group, working from a physical point of view, have brought to light an array of clinical and objective signs which seem to be of great diagnostic importance, and will eventually, it is felt, assist in determining an etiology in this disease, the frequency and sociologic importance of which is only beginning to be appreciated by the general medical profession.
Omitting the pathologic and biochemical findings, the clinical signs of recognized value are: alteration in the deep tendon reflexes, increased at first, diminished or absent in late stages; irregular
CORNELL WB. CYANOSIS IN DEMENTIA PRÆCOX. JAMA. 1912;LIX(25):2208-2210. doi:10.1001/jama.1912.04270140012004