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December 21, 1912


Author Affiliations

Pathologist, Hospital for Insane LINCOLN, NEB.

JAMA. 1912;LIX(25):2245-2246. doi:10.1001/jama.1912.04270140049016

This investigation into glycosuria of the insane was prompted by my interest in a case of mental aberration marked by melancholia and manifesting sufficient evidence of diabetes to raise the question of dependency of the psychic symptoms on that disease.

While our knowledge of the pathology of diabetes in the nervous system is incomplete it may be well to cite briefly the findings in a general way in order to note the impossibility of establishing a clear relation between glycosuria and mental disease on the basis of anatomic findings.

In the brain a variety of lesions in diverse locations have been associated with glycosuria. Spontaneous lesions as tumors, abscesses, hemorrhages and inflammatory thickenings, especially of the medulla and cerebellum near the place of Claude Bernard's puncture, but also in other parts of the brain, have been noted as causes of glycosuria. Tuberculosis of the hypophysis and the changes resulting in

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