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December 21, 1912

THE JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

JAMA. 1912;LIX(25):2258-2262. doi:10.1001/jama.1912.04270140062028
Abstract

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SATURDAY, DECEMBER 21, 1012

BARIUM POISONING AND LOCO-WEED DISEASE  Some time ago1 mention was made in these columns of the investigations of Dr. A. C. Crawford, then pharmacologist in the Bureau of Plant Industry, on the nature of loco-weed disease. This malady is a source of great loss to the stockmen of many of the grazing states of the West. Crawford concluded that, in certain regions at least, the inorganic constituents of the plants, especially barium compounds, are responsible for the symptoms of loco-poisoning. He asserted that the main toxic features described in stock on the range can be reproduced in rabbits by feeding extracts of certain loco-plants, and that a close analogy exists between the clinical symptoms and the pathologic findings in barium

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