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Article
January 10, 1903

A NOTE ON THE CHEMICAL DIAGNOSIS OF HYPERNEPHROMAS (SUPRARENAL TUMORS) OF THE KIDNEY.

JAMA. 1903;XL(2):91-92. doi:10.1001/jama.1903.92490020023001g
Abstract

In two recent publications1 I have shown that a watery extract of fresh suprarenal glands possesses the following properties:

Injected into the body of a dog or a rabbit it produces glycosuria (see also Blum's, Zuelzer's and Herter's recent publications).

It possesses the power of converting starch into dextrose and maltose and this power of the extract is lost on boiling.

It causes the blue color produced by iodin in a starch solution to disappear.

I am indebted to Dr. A. O. J. Kelly of Philadelphia, whose work on hypernephromas is well known, for the suggestion that possibly hypernephromas possessed properties similar to those shown to be possessed by the suprarenals themselves. It seemed possible that an investigation of this question might lead to an additional and important means of differentiating hypernephromas from tumors derived from proper renal structures. Inasmuch as it was thought that conclusive evidence

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