Epilepsy, independent of any gross disease or lesion of the brain, to which it is a sequence, has no distinctive morbid histology, so far as known. Gowers1 says : "In considering, then, the pathology of epilepsy, we must seek other evidence as to its nature than that which is afforded by the negative anatomy of the idiopathic disease, and must draw our inferences from the morbid changes in organic disease attended by convulsion, from the results of experiment, and from the facts ascertained by the clinical study of the disease."
It is seldom that an opportunity is offered for the study of the histology of the brain in idiopathic epilepsy before the development of those changes which are common to all forms of degeneration, and which obscure everything else. The occasional epileptic who dies of some intercurrent disease, during the earlier stages of his epilepsy, does not present any brain
TOMLINSON HA. EPILEPSY—ITS PSYCHOPATHOLOGY, AND MEDICOLEGAL RELATIONS.. JAMA. 1903;XL(3):147-149. doi:10.1001/jama.1903.92490030007002a