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Article
January 17, 1903

THE CLINICAL SIGNIFICANCE OF LEUCOCYTOSIS.

JAMA. 1903;XL(3):176-177. doi:10.1001/jama.1903.02490030040007
Abstract

Study of the blood has within the past two decades come to be an important aid in clinical diagnosis. Microscopic examination and culture methods often disclose the presence of parasites in the blood, and the specific agglutinating influence of the serum on colonies of certain bacteria constitutes a most valuable diagnostic guide, while a determination of the specific gravity, of the hemoglobin percentage and of the number of red and white corpuscles respectively, frequently furnishes useful information. An increase in the number of colorless corpuscles had long been known to occur physiologically during the digestive process, and pathologically in conjunction with leukemia. Under the condition first named the leucocytosis is transitory, while under the latter it is persistent.Increasing experience, however, showed that an increase in the number of leucocytes occurs in association with various inflammatory disorders, such as pneumonia, suppurative processes, etc., while the number remains unchanged or even undergoes

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