By reason of the part played by the liver in carbohydrate-metabolism glycosuria developing in the course of diseases of that viscus has been attributed to derangement of its function. Such a result, it was thought, is due to the entrance of the metabolic products directly into the general circulation, instead of passing through the liver, whose portal vessels are obstructed in consequence of the morbid process present. When it was shown that cirrhosis of the liver is but rarely attended with dextrosuria, it was suggested that the appearance of sugar in the urine under such circumstances is due to failure on the part of the liver cells, by reason of the existing disease, to retain the sugar brought to them. It was, however, found that glycosuria developed at times in the absence of disease of the liver and failed at other times to develop notwithstanding the presence of such disease.
LESIONS OF THE PANCREAS ASSOCIATED WITH CIRRHOSIS OF THE LIVER.. JAMA. 1903;XL(7):452-453. doi:10.1001/jama.1903.02490070038008